Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides.

نویسندگان

  • Anne-Laure Prunier
  • Brigitte Malbruny
  • Didier Tandé
  • Bertrand Picard
  • Roland Leclercq
چکیده

Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 9  شماره 

صفحات  -

تاریخ انتشار 2002